Epigenetics and Stress: “The moving finger writes; and, having writ, moves on.” – Omar Khayyam

There is a well-known connection between early life stress (ELS) and depression that develops in adolescence or the adult years. Individuals with severe ELS suffer from an up to three-fold higher incidence of depression as adults, a risk seen both in humans and in animal models. What has remained mysterious is the mechanism by which …