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The Toll of Lupus
Systemic lupus erythematosus (SLE) is a disease that affects an estimated 5 million people worldwide, and the disease usually presents between the ages of 15 and 44. Roughly 90% of the cases are in adult women although adult men and younger individuals of both sexes can develop SLE. Symptoms can include pain, extreme fatigue, hair […]
Viruses and Gene Therapy
There are around 6000 known genetic disorders that cause health problems with the number continuing to grow as more are discovered each year. The clinical effects can vary from just an increased risk for disease (e.g. breast cancer and BRCA1 or BRCA2 mutations) to an inevitably fatal condition (e.g. progeria). Many of the more frequently […]
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A Mutational Limit for Lifespan?
It has long been known that mammalian lifespan roughly correlates with animal size, i.e. larger animals live longer than smaller ones. Mice generally live less than 2 years, your average dog lives 10-13 years, and humans have a typical lifespan of 73 years. What is less clear is the mechanistic basis for this observation. Differences […]
New Predictive Biomarkers for Cardiovascular Disease
Cardiovascular disease (CVD) is a catchall term for any medical condition affecting the heart or the blood vessels. Serious cardiovascular health issues include heart attacks, strokes, and heart failure, events often preceded by hypertension (high blood pressure) and/or atherosclerosis (plaque in the arteries). Even with medical monitoring and a large array of cardiovascular drugs, CVD […]
A Giant Among Us
Bacteria are single-cell wonders. They live, grow, reproduce, and can perform all the functions of life as solitary organisms independent from their brethren. With rich and complex genetics, these microbes vary enormously in their properties and populate every possible niche from the frigid Arctic to the interior of our bodies. But one common feature is […]
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