I am a professional scientist in the biological arena, and the fundamental goal of my profession is to seek truth, understanding, and knowledge. We don’t always get it right, but we always strive to reach the absolute truth even if progress is slow and incremental. We are taught to follow the evidence wherever it takes …
Bioengineered Yeast Combat Clostridium difficile
Clostridium difficile (C. diff for short) is an environmental bacterium that has become increasingly common as an opportunistic pathogen. Like its relatives, Clostridium botulinum (the cause of botulism) and Clostridium tetani (the cause of tetanus), C. diff is a spore-forming organism. Spores are dormant forms of bacteria that are very stable and resistant structures. Their …
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Rubella Has a Family at Last
Some viruses, such as the human papillomaviruses (HPVs), have co-evolved with mankind throughout evolutionary history. These ancient human viruses often cause silent infections and may establish persistent infections that last for years to decades. Other viruses, often ones associated with common human acute diseases, entered the human population only within the last few millennia. Typically, …
COVID Vaccine Hesitancy
According to national polls, a significant fraction of Americans currently remains hesitant to take any of the three approved SARS-CoV-2 vaccines (Pfizer, Moderna, and Johnson & Johnson). I’ve seen several different reasons given, but one common reason is a safety concern. It is the fear that the rapid development and deployment of the SARS-CoV-2 vaccines …
The Gut-Brain Connection
Our gastrointestinal system is teeming with diverse bacteria that collectively comprise our gut microbiome. These bacteria contribute to our digestive capability as well as more broadly influencing our overall health and wellbeing. As the bacteria in our gut digest our food they produce and excrete their own biomolecules that we call metabolites. Bacterial metabolites can …
COVID-19 Update – Variations on a Theme
The news is filled with alarming stories about new variants of SARS-CoV-2 that were isolated in recent weeks. These variants are versions of the original SARS-CoV-2 virus that have acquired mutations. Mutations are a natural and regular occurrence that happens when the parental viral genome replicates during the process of making progeny viruses. In an …
Famous Virus Tales of Christmas Past
To start December here are some versions of Xmas tales that only a virologist would love. Happy holidays to all! “Twas the Night Before Coronavirus” - Santa isn’t the only thing sneaking into the house this winter! “A Christmas Calicivirus” - A crotchety old man discovers that it is better to give than receive (viruses that …
COVID-19 – Are We Nearing the Endgame?
I suspect that everyone has heard the highly encouraging news this week from two vaccine manufacturers, Pfizer/BioNTech and Moderna. Both companies released the first phase 3 trial preliminary results this week and based on these early data each of their vaccines is highly effective after 2 doses. In the case of Pfizer’s vaccine, the initial …
Nobel for CRISPR
I just wanted to add my congratulations to the 2020 Nobel Prize in Chemistry winners, Drs. Jennifer Doudna and Emmanuelle Charpentier. Only the 6th and 7th women to receive the Chemistry Nobel Prize, Doudna and Charpentier received the award for making the bacterial CRISPR/Cas9 system into the most powerful genetic tool of the 21st century. …
Human Gene Editing – Is the Future Now?
Many human diseases are the result of genetic errors, commonly called mutations. You can think of the four nucleotides (A, C, T, and G) that comprise our DNA as the letters of our genetic alphabet with these nucleotide letters making up our genes which are the “words” of our genome. Mutations result from changes in …
In Other Viral News
While SARS-CoV-2 continues to dominate our news and daily lives, research on other important viruses continues unabated in research labs around the world. An important recent paper in Nature Communications used multiple approaches to decode the genome of herpes simplex virus type 1 (HSV-1). HSV-1 causes oral lesions commonly known as “cold sores” or “fever …
