COVID Vaccine Hesitancy

According to national polls, a significant fraction of Americans currently remains hesitant to take any of the three approved SARS-CoV-2 vaccines (Pfizer, Moderna, and Johnson & Johnson). I’ve seen several different reasons given, but one common reason is a safety concern. It is the fear that the rapid development and deployment of the SARS-CoV-2 vaccines …

COVID-19 Update – Variations on a Theme

The news is filled with alarming stories about new variants of SARS-CoV-2 that were isolated in recent weeks. These variants are versions of the original SARS-CoV-2 virus that have acquired mutations. Mutations are a natural and regular occurrence that happens when the parental viral genome replicates during the process of making progeny viruses. In an …

COVID-19 Update – The Kinase Connection

Vaccines are a critical factor for stopping the SARS-CoV-2 pandemic as vaccines will help protect uninfected individuals, contribute to herd immunity, and restrict the spread of the virus. However, even after successful vaccines are developed it could take years to manufacture hundreds of millions of doses, to distribute them throughout the world, and to vaccinate …

Coronavirus Update – A Vaccine Primer

Vaccination is based on the concept of immune memory. When we encounter a new pathogen, we mount an immune response that helps us recover from the infection and also creates immune memory. This process typically takes 1-2 weeks to develop, so we often get sick before there is sufficient immunity to rid our bodies of …

Coronavirus and the Host Response

The SARS-CoV-2 pandemic continues to accelerate in the U.S. and many other countries. As a potential vaccine is likely over a year away, there is great interest in finding an effective antiviral drug. Numerous antiviral drugs were developed for other viruses and many of these are being tested. Additionally, there are many other existing drugs …

Coronavirus Update

The COVID-19 disease caused by the new SARS-CoV-2 virus has not been as easily contained as the related SARS outbreak in 2003. Cases continue to mount in China with spread into roughly 30 other countries so far. New evidence suggests possible fecal transmission as well as by aerosol and close contact with infected individuals. Infected …

A Coronavirus by Any Other Name

The new coronavirus outbreak is causing fear, social anxiety, and economic disruption worldwide as we struggle to contain its spread and find treatments or vaccines. Amid the medical and social issues comes the confusing matter of nomenclature, i.e. what do we call this virus and the disease it causes? This week the World Health Organization …